Chronic kidney disease alters intestinal microbial flora

Diversity of the human intestinal microbial flora.

The human endogenous intestinal microflora is an essential "organ" in providing nourishment, regulating epithelial development, and instructing innate immunity; yet, surprisingly, basic features remain poorly described. We examined 13,355 prokaryotic ribosomal RNA gene sequences from multiple colonic mucosal sites and feces of healthy subjects to improve our understanding of gut microbial diver...

Vitamin deficiencies in chronic kidney disease

Endocrine disorders in chronic kidney disease

Background and Objective: Endocrine disorders are common in patients with chronic kidney disease (CKD). The aim of the present study is reviewing available literature to give a deep understanding of complexities of endocrine disorders in chronic kidney disease. Methods: A narrative reviewing method based on the available literature was approached. Findings: Generally, when renal function de...

Chronic kidney disease alters vascular smooth muscle cell phenotype.

Vascular access dysfunction associated with arteriovenous grafts and fistulas contributes to the morbidity and mortality of chronic kidney disease (CKD) patients receiving hemodialysis. We hypothesized that the uremic conditions associated with CKD promote a pathophysiological vascular smooth muscle cell (VSMC) phenotype that contributes to neointimal hyperplasia. We analyzed the effect of cult...

Effect of normal microbial flora on intestinal surface area1

GORDON, HELMUT A., AND EDITH BRUCKNER-KARDOSS. Efect of normal microbial flora on intestinal surface area. Am. J. Physiol. 201 (I) : I 75-178. I g6 I .-The mucosal surface area of the small intestine was determined in young adult, germfree and conventional rats. On the average, the germfree values were found to be 307~ lower than those of conventional animals. This reduction was pronounced in t...